Binju Wang

2 weeks ago | onlinelibrary.wiley.com | Lina Dong |Pengfei Li |Binju Wang

Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description jcc70093-sup-0001-supinfo.docxWord 2007 document , 781.6 KB Data S1. Supporting Information. References 1, , , and , “Recent Developments in Free Energy Calculations for Drug Discovery,” Frontiers in Molecular Biosciences 8 (2021): 712085.

Sep 14, 2023 | nature.com | Lu Yu |Yue Zhao |Changlin Tian |Binju Wang

AbstractState-of-the-art non-natural photoenzymatic catalysis typically relies on either ultraviolet light activation or the formation of electron donor–acceptor complexes. Inspired by nature, herein we develop a biocatalytic scheme based on direct visible-light excitation of flavoprotein to achieve stereocontrolled intermolecular radical hydroarylation of alkenes with electron-rich arenes.

May 15, 2023 | pubs.acs.org | Yuqing Zhang |Yanhui Chen |Qingyu Tian |Binju Wang

A palladium-catalyzed multicomponent cascade reaction of aryl iodides, oxanorbornadiene, and diborns to access (Z)-alkenylborons is reported. This transformation proceeds through the sequential carbopalladation/boronation/retro-Diels–Alder domino reaction. The oxanorbornadiene used in this reaction serves as an acetylene surrogate, which is generated via a retro-Diels–Alder reaction.