Changlin Tian

Dec 18, 2023 | nature.com | Lu Yu |Yue Zhao |Changlin Tian |Yong Liang

AbstractEnzymes are recognized as exceptional catalysts for achieving high stereoselectivities1,2,3, but their ability to control the reactivity and stereoinduction of free radicals lags behind that of chemical catalysts4. Thiamine diphosphate (ThDP)-dependent enzymes5 are well-characterized systems that inspired the development of N-heterocyclic carbenes (NHCs)6,7,8 but have not yet been proved viable in asymmetric radical transformations.

Sep 14, 2023 | nature.com | Lu Yu |Yue Zhao |Changlin Tian |Binju Wang

AbstractState-of-the-art non-natural photoenzymatic catalysis typically relies on either ultraviolet light activation or the formation of electron donor–acceptor complexes. Inspired by nature, herein we develop a biocatalytic scheme based on direct visible-light excitation of flavoprotein to achieve stereocontrolled intermolecular radical hydroarylation of alkenes with electron-rich arenes.

Jun 30, 2023 | nature.com | Changlin Tian

Dear Editor,In plant, the family of voltage-gated potassium channel is crucial for K+ uptake, release, and distribution, playing important roles in plant growth and development1,2. Among these channels, the Stelar K+ outward rectifier channel (SKOR) functions as a K+ efflux channel for long-distance distribution of K+ from roots to the upper parts of the plant3,4. There are only two structures of voltage-gated K+ channels, KAT1 and AKT1 from Arabidopsis, reported to date5,6,7.