Binyou Wang

Nov 4, 2024 | journals.plos.org | Binyou Wang |Sichuan province |Yong Zhou |Han Yu

DiscussionThis study marks the first exploration of the associations between three nutritional indices (PNI, GNRI and CONUT) and cognitive performance in hospitalized individuals with stable schizophrenia. The findings revealed that only the PNI value was significantly correlated with the cognitive function, while the GNRI and CONUT scores failed to exhibit similar associations. Moreover, the PNI score can be easily calculated from routine laboratory blood analyses.

Aug 13, 2024 | journals.plos.org | Ling Wei |Sichuan province |Binyou Wang |Yilin Wang

Loading metrics Open Access Peer-reviewedResearch Article Citation: Wei L, Wang B, Wang Y (2024) Low handgrip strength with asymmetry is associated with elevated all-cause mortality risk in older Chinese adults with abdominal obesity. PLoS ONE 19(8): e0306982. https://doi.org/10.1371/journal.pone.0306982Editor: Masaki Mogi, Ehime University Graduate School of Medicine, JAPANReceived: February 27, 2024; Accepted: June 26, 2024; Published: August 13, 2024Copyright: © 2024 Wei et al.

Jul 31, 2024 | pubs.acs.org | Kasun Gamage |Binyou Wang |Eldon R. Hard |thong van

IntroductionClick to copy section linkSection link copied!α-Syn can be subjected to a variety of posttranslational modifications (PTMs) that have the potential to affect the protein’s aggregation properties. (1−3) One PTM of particular interest is an intracellular form of glycosylation termed O-GlcNAc, which is the addition of the monosaccharide N-acetylglucosamine to serine and threonine residues.

May 9, 2024 | biorxiv.org | Kasun Gamage |Binyou Wang |Eldon R. Hard |thong van

AbstractThe intrinsically disordered protein alpha-Synuclein is identified as a major toxic aggregate in Parkinson's as well as several other neurodegenerative diseases. Recent work on this protein has focused on the effects of posttranslational modifications on aggregation kinetics. Among these, O-GlcNAcylation of alpha-Synuclein has been observed to inhibit the aggregation propensity of the protein.

May 3, 2024 | cell.com | Binyou Wang |Matthew R. Pratt

Small heat shock proteins (sHSPs) play key roles in cellular stress and several human diseases. The direct effects of some post-translational modifications (PTMs) on certain sHSPs have been characterized, raising the possibility that small molecules could be used to modulate these modifications and indirectly up- or downregulate sHSP activity.