Biprodev Sarker

Aug 22, 2023 | biorxiv.org | Min Zeng |Biprodev Sarker |Vanessa Vu |Stephen N. Rondthaler

AbstractProgrammable intercellular signaling using components of naturally-occurring quorum sensing can allow for coordinated functions to be engineered in microbial consortia. LuxR-type transcriptional regulators are widely used for this purpose and are activated by homoserine lactone (HSL) signals. However, they often suffer from imperfect molecular discrimination of structurally similar HSLs, causing misregulation within engineered consortia containing multiple HSL signals.

Aug 18, 2023 | biorxiv.org | Min Zeng |Biprodev Sarker |Nathaniel Howitz

AbstractA universal biochemical signal for bacterial cell-cell communication could facilitate programming dynamic responses in diverse bacterial consortia. However, the classical quorum sensing paradigm is that gram-negative and gram-positive bacteria generally communicate via homoserine lactones (HSL) or oligopeptide molecular signals, respectively, to elicit population responses.