Stephen N. Rondthaler

Aug 22, 2023 | biorxiv.org | Min Zeng |Biprodev Sarker |Vanessa Vu |Stephen N. Rondthaler

AbstractProgrammable intercellular signaling using components of naturally-occurring quorum sensing can allow for coordinated functions to be engineered in microbial consortia. LuxR-type transcriptional regulators are widely used for this purpose and are activated by homoserine lactone (HSL) signals. However, they often suffer from imperfect molecular discrimination of structurally similar HSLs, causing misregulation within engineered consortia containing multiple HSL signals.