Bjorn Klabunde

Apr 16, 2024 | biorxiv.org | Ziyuan Wu |Ole Baek |Jingren Zhong |Bjorn Klabunde

AbstractTwo distinct defense strategies, resistance and tolerance, enable a host to survive infectious diseases. Newborns, constrained by limited energy reserves, predominantly rely on tolerance to cope with infection. However, this approach may fail as pathogen levels surpass a critical threshold, prompting a shift to resistance that can lead to dysregulated immune responses and sepsis. The mechanisms governing the interplay between tolerance and resistance in newborns remain poorly understood.

Feb 27, 2024 | biorxiv.org | Ziyuan Wu |Ole Baek |Jingren Zhong |Bjorn Klabunde

AbstractUpon infection, mammals utilize either disease resistance, which seeks to eliminate pathogens at the cost of potential tissue damage, or disease tolerance, which reduces physiological damage without killing the pathogen. Newborns, constrained by limited energy reserves, predominantly rely on disease tolerance strategies to cope with infection.