Jingren Zhong

May 17, 2024 | biorxiv.org | Jingren Zhong |Ole Baek |Richard Doughty |Benjamin Meyer Joergensen

AbstractBackground: Premature infants are highly susceptible to infections that can lead to sepsis with life-threatening organ dysfunctions. The clinical practice of high parenteral glucose supply in preterm infants can exacerbate infection outcomes through excessive glycolysis-induced inflammatory response. This in turn can affect the health of vital preterm organs, including the brain and kidneys.

Apr 16, 2024 | biorxiv.org | Ziyuan Wu |Ole Baek |Jingren Zhong |Bjorn Klabunde

AbstractTwo distinct defense strategies, resistance and tolerance, enable a host to survive infectious diseases. Newborns, constrained by limited energy reserves, predominantly rely on tolerance to cope with infection. However, this approach may fail as pathogen levels surpass a critical threshold, prompting a shift to resistance that can lead to dysregulated immune responses and sepsis. The mechanisms governing the interplay between tolerance and resistance in newborns remain poorly understood.

Feb 27, 2024 | biorxiv.org | Ziyuan Wu |Ole Baek |Jingren Zhong |Bjorn Klabunde

AbstractUpon infection, mammals utilize either disease resistance, which seeks to eliminate pathogens at the cost of potential tissue damage, or disease tolerance, which reduces physiological damage without killing the pathogen. Newborns, constrained by limited energy reserves, predominantly rely on disease tolerance strategies to cope with infection.

Oct 27, 2023 | onlinelibrary.wiley.com | Jing Yi Sun |Jingren Zhong |Tik Muk |Halise Gül Akıllıoğlu

1 Introduction Relative to term infants, preterm infants are born with immature organs and altered immune functions, making them vulnerable to neonatal infections and inflammation.[1, 2] Postnatal inflammation and infections have now become the leading causes of neonatal death and morbidity in children, and such effects may induce detrimental effects across multiple organs (e.g., lung, gut, kidney, and brain).[3, 4] Many environmental factors (e.g., birth mode, feeding, antibiotics, and...

Jun 5, 2023 | biorxiv.org | Per Torp Sangild |Duc Nguyen |Jingren Zhong |Thomas Thymann

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