Björn Morén

Feb 2, 2023 | rupress.org | Elin C Larsson |Björn Morén |Robert G. Parton |Kerrie-ann McMahon

Caveolae display atypical dynamics in the sense that such invaginations are stably associated with the PM over time. Yet, the mechanisms controlling the stability and fission of the caveola neck are not fully understood. Herein, we have studied the role of Dyn2 on caveola dynamics in living cells using TIRF microscopy and single particle tracking. In contrast to its role in CCV fission, we find that Dyn2 acts as a stabilizing protein, increasing the time caveolae spend at the PM.