Bonnie E.J. Maven

Oct 19, 2023 | cell.com | Bonnie E.J. Maven |Casey A. Gifford

Highlights•Deep learning (BPNet) identified ISL1-NKX2.5 cardiac-specific complex•ISL1-NKX2.5 complex drives a cardiac-specific regulatory network•ISL1-NKX2.5 interaction is necessary for ISL1 cardiac localizationSummaryCongenital heart disease often arises from perturbations of transcription factors (TFs) that guide cardiac development.