Casey A. Gifford

Jan 10, 2024 | nature.com | Fang Liu |Rowan Matney |Ryan D. Leib |Russell B. Corbett-Detig |Judith Frydman |Casey A. Gifford | +4 more

AbstractThe evolution of reproductive barriers is the first step in the formation of new species and can help us understand the diversification of life on Earth. These reproductive barriers often take the form of hybrid incompatibilities, in which alleles derived from two different species no longer interact properly in hybrids1,2,3.

Nov 29, 2023 | nature.com | Angelo Pelonero |Lin Ye |Michael Alexanian |Frances Koback |Casey A. Gifford

AbstractMaternal diabetes mellitus is among the most frequent environmental contributors to congenital birth defects, including heart defects and craniofacial anomalies, yet the cell types affected and mechanisms of disruption are largely unknown. Here, using multimodal single-cell analyses, we show that maternal diabetes affects the epigenomic landscape of specific subsets of cardiac and craniofacial progenitors during embryogenesis.

Oct 19, 2023 | cell.com | Bonnie E.J. Maven |Casey A. Gifford

Highlights•Deep learning (BPNet) identified ISL1-NKX2.5 cardiac-specific complex•ISL1-NKX2.5 complex drives a cardiac-specific regulatory network•ISL1-NKX2.5 interaction is necessary for ISL1 cardiac localizationSummaryCongenital heart disease often arises from perturbations of transcription factors (TFs) that guide cardiac development.