Brain imaging

May 16, 2024 | academic.oup.com | Vrije Universiteit Amsterdam |Amsterdam Neuroscience |Brain imaging

This scientific commentary refers to ‘Characterizing brain tau and cognitive decline along the amyloid timeline in Alzheimer’s disease’ by Cody et al. (https://doi.org/10.1093/brain/awae116). The current conceptualization of Alzheimer’s disease is strongly driven by the amyloid cascade hypothesis,1 which has provided the leading framework for investigating and understanding Alzheimer’s disease pathophysiology.

Dec 4, 2023 | jamanetwork.com | Niklas Mattsson-Carlgren |Amsterdam Neuroscience |Brain imaging |Erik Stomrud

Key PointsQuestion  Can plasma biomarkers serve as prescreening tools to identify individuals suitable for treatment with antiamyloid immunotherapies in Alzheimer disease, ie, amyloid β (Aβ)–positive individuals who do not yet have too much tau in the brain? Findings  This cohort study demonstrated the efficacy of using plasma p-tau217 values to both rule out Aβ-negative individuals and identify Aβ-positive individuals who are likely to have high tau burden.

Sep 9, 2023 | frontiersin.org | Brain imaging

Affective processing plays a crucial role in human life. Deficits in affective processing are accompanied by mental problems including depression, anxiety, and addiction. Non-invasive brain stimulation methodologies such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) have become more and more popular in modulating a wide range of cognitive processing.

Mar 9, 2023 | tinyurl.com | Vrije Universiteit Amsterdam |Amsterdam Neuroscience |Brain imaging |ten Kate

PDF Split View Article contents Figures & tables Video Audio Supplementary Data Emma M Coomans , Genetically identical twin-pair difference models support the amyloid cascade hypothesis, Brain, Volume 146, Issue 9, September 2023, Pages 3735–3746, https://doi.org/10.1093/brain/awad077 Close Alzheimer’s disease, amyloid-β, tau, neurodegeneration, cognition, identical twins Introduction The amyloid cascade hypothesis has provided the leading framework for investigating and understanding...