Brandon Coke

2 months ago | nature.com | Matthew Sherwood |Thiago G Mitsugi |Carolini Kaid |Brandon Coke |Mayana Zatz |Kevin Maringer | +1 more

AbstractBrain tumours disproportionately affect children and are the largest cause of paediatric cancer-related death. Novel therapies that engage the immune system, such as oncolytic viruses (OVs), hold great promise and are desperately needed. Zika virus (ZIKV) infects and destroys aggressive cells from multiple paediatric central nervous system (CNS) tumours. Despite this, the molecular mechanisms underpinning this response are largely unknown.

Oct 14, 2024 | biorxiv.org | Ben Draper |Siyuan Wang |Brandon Coke |Ahood Al-Eidan

AbstractUbiquitin-specific protease 7 (USP7) is implicated in many cancers including colorectal cancer in which it regulates cellular pathways such as Wnt signalling and the P53-MDM2 pathway. With the discovery of small-molecule inhibitors, USP7 has also become a promising target for cancer therapy, and therefore systematically identifying USP7 deubiquitinase interaction partners and substrates has become an important goal.