Braulio A. Marfil-Garza

Jun 21, 2024 | biorxiv.org | James Lyon |Alice Carr |Nancy Smith |Braulio A. Marfil-Garza

AbstractHuman islets from deceased organ donors have made important contributions to our understanding of pancreatic endocrine function and continue to be an important resource for research studies aimed at understanding, treating, and preventing diabetes. Understanding the impacts of isolation and culture upon the yield of human islets for research is important for planning research studies and islet distribution to distant laboratories.

Dec 4, 2023 | nature.com | Braulio A. Marfil-Garza |Alexander U. Ernst |Andrew R. Pepper |Ashim Datta |Ye-Zi You |Minglin Ma | +1 more

AbstractCellular therapies for type-1 diabetes can leverage cell encapsulation to dispense with immunosuppression. However, encapsulated islet cells do not survive long, particularly when implanted in poorly vascularized subcutaneous sites.