James Lyon

Jan 7, 2025 | cell.com | Jessica D. Ewald |Yao Lu |Cara E. Ellis |Jessica Worton |Jelena Kolic |Shugo Sasaki | +25 more

ForumVolume 37, Issue 1p7-11 1Institute of Parasitology, McGill University, Montreal, QC, Canada 2Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA 3Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada 4Department of Pharmacology, University of Alberta, Edmonton, AB, Canada 5Department of Surgery, University of Alberta, Edmonton, AB, Canada 6Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia,...

Jan 7, 2025 | cell.com | Jessica D. Ewald |Yao Lu |Cara E. Ellis |Jessica Worton |Jelena Kolic |Shugo Sasaki | +25 more

ForumVolume 37, Issue 1p7-11 1Institute of Parasitology, McGill University, Montreal, QC, Canada 2Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA 3Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada 4Department of Pharmacology, University of Alberta, Edmonton, AB, Canada 5Department of Surgery, University of Alberta, Edmonton, AB, Canada 6Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia,...

Jul 2, 2024 | cell.com | Jelena Kolic |Wenqing Sun |Haoning Cen |Jessica D. Ewald |Jason C. Rogalski |Shugo Sasaki | +14 more

Keywordshuman isletstype 2 diabetesstem cell-derived isletsinsulin secretionproteomicsmacronutrientsRNA-seqIntroductionInsulin is released by pancreatic islet beta cells in response to nutrient stimuli to maintain energy homeostasis. The major driver of insulin secretion is glucose. However, proteins and fats may also modulate insulin release, and the effects of non-carbohydrate nutrients on insulin secretion remain underexplored.

Jun 21, 2024 | biorxiv.org | James Lyon |Alice Carr |Nancy Smith |Braulio A. Marfil-Garza

AbstractHuman islets from deceased organ donors have made important contributions to our understanding of pancreatic endocrine function and continue to be an important resource for research studies aimed at understanding, treating, and preventing diabetes. Understanding the impacts of isolation and culture upon the yield of human islets for research is important for planning research studies and islet distribution to distant laboratories.

May 30, 2024 | harboroughmail.co.uk | James Lyon |James LyonContributor

Watch more of our videos on Shots! and live on Freeview channel 276Visit Shots! nowLocal law firm wins 'Large Law Firm of the Year' at 2024 Leicestershire Law Society Awards. On Friday 17th May local law firm, Josiah Hincks Solicitors, were crowned Leicestershire's 'Large Law Firm of the Year'.