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Oct 27, 2023 | 
pnas.org | Alessandro Taberna |Tatiana Filatova | |Brayton Noll
Localization of PPM1H phosphatase tunes Parkinson’s disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesisEdited by Peter Novick, University of California, San Diego, CA; received August 31, 2023; accepted September 23, 2023SignificancePathogenic, hyperactive LRRK2 (Leucine Rich Repeat Kinase 2) kinase is strongly linked to Parkinson’s disease and LRRK2 phosphorylates a subset of Rab GTPases that are master regulators of membrane trafficking.
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Oct 27, 2023 | 
pnas.org | Alessandro Taberna |Tatiana Filatova | |Brayton Noll
SignificanceWhile SARS-CoV-2 transmission continues, adherence to nonpharmaceutical interventions (NPIs) is now largely based on individual decision-making, which itself depends on infection levels, adherence cost, and perceived risk of an infection.
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Oct 26, 2023 | 
pnas.org | Alessandro Taberna |Tatiana Filatova | |Brayton Noll
Diacylglycerol-dependent hexamers of the SNARE-assembling chaperone Munc13-1 cooperatively bind vesiclesEdited by Axel Brunger, Stanford University, Stanford, CA; received April 14, 2023; accepted September 28, 2023SignificanceMunc13-1 is a molecular chaperon that facilitates recruitment and docking of synaptic vesicles at the active zone of the synapse.
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Oct 26, 2023 | 
pnas.org | Alessandro Taberna |Tatiana Filatova | |Brayton Noll
Cytosolic iron–sulfur protein assembly system identifies clients by a C-terminal tripeptideMelissa D. Marquez https://orcid.org/0000-0002-9867-1130, Carina Greth, Anastasiya Buzuk https://orcid.org/0009-0007-1549-5068, +9 , Yaxi Liu, Catharina M. Blinn, Simone Beller https://orcid.org/0009-0005-9389-3796, Laura Leiskau, Anthony Hushka https://orcid.org/0000-0001-9812-384X, Kassandra Wu, Kübra Nur https://orcid.org/0009-0001-9315-7298, Daili J. A. Netz, Deborah L.
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Oct 26, 2023 | 
pnas.org | Alessandro Taberna |Tatiana Filatova | |Brayton Noll
SignificanceUse of AI in the production of text through Large Language Models (LLMs) is widespread and growing, with potential applications in journalism, copywriting, academia, and other writing tasks. As such, it is important to understand whether text produced or summarized by LLMs exhibits biases. The studies presented here demonstrate that the LLM ChatGPT-3 reflects human biases for certain types of content in its production.
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Oct 26, 2023 | 
pnas.org | Alessandro Taberna |Tatiana Filatova | |Brayton Noll
M. Konarska, W. Filipowicz, H. J. Gross, RNA ligation via 2′-phosphomonoester, 3′,5′-phosphodiester linkage: Requirement of 2′,3′-cyclic phosphate termini and involvement of a 5′-hydroxyl polynucleotide kinase. Proc. Natl. Acad. Sci. U.S.A. 79, 1474–1478 (1982). C. L. Greer, C. L. Peebles, P. Gegenheimer, J. Abelson, Mechanism of action of a yeast RNA ligase in tRNA splicing. Cell 32, 537–546 (1983). S. M. McCraith, E. M.
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Oct 26, 2023 | 
pnas.org | Alessandro Taberna |Tatiana Filatova | |Brayton Noll
Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clusteringYing Lai https://orcid.org/0000-0001-5347-5155, Chunyu Zhao, Zhiqi Tian https://orcid.org/0000-0001-7027-9527, +16 , Chuchu Wang https://orcid.org/0000-0003-2015-7331, Jiaqi Fan, Xiao Hu, Jia Tu, Tihui Li, Jeremy Leitz, Richard A.
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Oct 25, 2023 | 
pnas.org | Alessandro Taberna |Tatiana Filatova | |Brayton Noll
Inhaled mRNA nanoparticles dual-targeting cancer cells and macrophages in the lung for effective transfection Zhongmin Tang https://orcid.org/0000-0002-1532-8004, Xinru You, Yufen Xiao, +8 , Wei Chen https://orcid.org/0000-0002-2909-3023, Yongjiang Li, Xiangang Huang, Haijun Liu, Fan Xiao https://orcid.org/0000-0003-3429-5241, Chuang Liu https://orcid.org/0000-0002-2445-0845, Seyoung Koo, Na Kong, and Wei Tao https://orcid.org/0000-0002-4277-3728 [email protected] -8Authors Info &...
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Oct 25, 2023 | 
pnas.org | Alessandro Taberna |Tatiana Filatova | |Brayton Noll
SignificanceA large-scale analysis of high-resolution protein structures suggests that amino acid pairs constitute another layer of ordered structure, more local than the conventionally defined secondary structures. We develop a cross-peptide-bond Ramachandran plot that captures the conformational preferences of the amino acid pairs and demonstrate that it conveys biologically meaningful information, not apparent in the traditional Ramachandran plot.
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Oct 25, 2023 | 
pnas.org | Alessandro Taberna |Tatiana Filatova | |Brayton Noll
R. L. Buckner, Memory and executive function in aging and AD: Multiple factors that cause decline and reserve factors that compensate. Neuron 44, 195–208 (2004). T. Hedden, J. D. Gabrieli, Insights into the ageing mind: A view from cognitive neuroscience. Nat. Rev. Neurosci. 5, 87–96 (2004). M. E. Bouton, S. Maren, G. P. McNally, Behavioural and neurobiological mechanisms of pavlovian and instrumental extinction learning. Physiol. Rev. 101, 611–681 (2021). J. Kim et al., Amygdala depotentiation and fear extinction.
