Brennan Abanades

May 21, 2024 | biorxiv.org | Bora Guloglu |Brennan Abanades |Vijaykumar Karuppiah |Nele P Quast

AbstractT-cell receptor (TCR) structures are currently under-utilised in early-stage drug discovery and repertoire-scale informatics. Here, we leverage a large dataset of solved TCR structures from Immunocore to evaluate the current state-of-the-art for TCR structure prediction, and identify which regions of the TCR remain challenging to model.