Vijaykumar Karuppiah

Nov 22, 2024 | nature.com | Rachel L. Paterson |Rakesh Kulkarni |Richard Suckling |Vijaykumar Karuppiah |Robert Pengelly |José Donoso | +14 more

AbstractThe non-polymorphic HLA-E molecule offers opportunities for new universal immunotherapeutic approaches to chronic infectious diseases. Chronic Hepatitis B virus (HBV) infection is driven in part by T cell dysfunction due to elevated levels of the HBV envelope (Env) protein hepatitis B surface antigen (HBsAg).

May 21, 2024 | biorxiv.org | Bora Guloglu |Brennan Abanades |Vijaykumar Karuppiah |Nele P Quast

AbstractT-cell receptor (TCR) structures are currently under-utilised in early-stage drug discovery and repertoire-scale informatics. Here, we leverage a large dataset of solved TCR structures from Immunocore to evaluate the current state-of-the-art for TCR structure prediction, and identify which regions of the TCR remain challenging to model.