Brennan C. Kahan

Jan 23, 2024 | bmj.com | Brennan C. Kahan |Tim Morris |Suzie Cro

Brennan C Kahan, principal research fellow1, Tim P Morris, principal research fellow1, Suzie Cro, senior lecturer2 1MRC Clinical Trials Unit at UCL, University College London, London, UK 2Imperial Clinical Trials Unit, School of Public Health, Imperial College London, London, UK Estimands help researchers to pinpoint their exact research question, say Brennan C Kahan and colleagues Many researchers, like ourselves, will remember being taught to select a study’s analysis method based on the...

Jun 26, 2023 | onlinelibrary.wiley.com | Lisa N Yelland |Jennie Louise |Brennan C. Kahan |Tim Morris

1 INTRODUCTION Stratified randomisation is a popular approach for randomly assigning participants to treatment groups in clinical trials.1-3 It is a member of a broader class of covariate-adaptive randomisation procedures2 that take baseline covariates into account when allocating participants to treatment groups, thus preventing imbalance between the randomised groups on the chosen covariates at the trial design stage.4 To implement stratified randomisation, participants are divided into...