Brian Applegate

2 months ago | octnews.org | Brian Applegate |Frank D. Macías-Escrivá |John S. Oghalai |Wihan Kim

July 28, 2021 | Otolaryngology | University of Southern CaliforniaWe describe an optical coherence tomography and vibrometry system designed for portable hand-held usage in the otology clinic on awake patients. The system provides clinically relevant point-of-care morphological imaging with 14-44 µm resolution and functional vibratory measures with sub-nanometer sensitivity.

Oct 26, 2024 | nature.com | Brian Applegate

AbstractEndolymphatic hydrops, increased endolymphatic fluid within the cochlea, is the key pathologic finding in patients with Meniere’s disease, a disease of episodic vertigo, fluctuating hearing loss, tinnitus, and aural fullness. Endolymphatic hydrops also can occur after noise trauma and its presence correlates with cochlear synaptopathy, a form of hearing loss caused by reduced numbers of synapses between hair cells and auditory nerve fibers.

Jul 10, 2024 | octnews.org | Brian Applegate

University of Southern California Receives a 2024 NIH Grant for $195,309 for High-Speed, Low-Cost, Image Remapping Spectral Domain Full-Field Optical Coherence Tomography for Retinal Imaging. The principal investigator is Brian Aplegate. Below is a summary of the proposed study. Optical Coherence Tomography (OCT) has profoundly impacted diagnostic imaging of the human retina, enabling accurate and early diagnosis of retinal disease.