Brian D. Piening

May 17, 2024 | nature.com | Brian D. Piening |Maedeh Mohebnasab |Bo Xia |Jeffrey S. Stern |Weimin Zhang |Jacqueline I. Kim | +20 more

AbstractIn a previous study, heart xenografts from 10-gene-edited pigs transplanted into two human decedents did not show evidence of acute-onset cellular- or antibody-mediated rejection. Here, to better understand the detailed molecular landscape following xenotransplantation, we carried out bulk and single-cell transcriptomics, lipidomics, proteomics and metabolomics on blood samples obtained from the transplanted decedents every 6 h, as well as histological and transcriptomic tissue profiling.

May 24, 2023 | science.org | Lubka T. Roumenina |Brian D. Piening |Jackie Oberst

Share: Lubka Roumenina, Ph.D.Speaker Brian Piening, Ph.D.Speaker Jackie Oberst, Ph.D.Moderator This webinar is brought to you by the Science/AAAS Custom Publishing Office. Spatial biology is an emerging field that seeks to understand the spatial organization of cells and how it affects their function. In the context of immuno-oncology, spatial biology has proven to be a critical tool for understanding the interactions between cellular and non-cellular components—cancer cells, immune system,...