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Aug 17, 2024 | 
mdpi.com | Shirong Liu |Wentao Jia |Qianyun Wang |Weimin Zhang
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Jun 18, 2024 | 
mdpi.com | Shirong Liu |Wentao Jia |Weimin Zhang
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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May 17, 2024 | 
nature.com | Brian D. Piening |Maedeh Mohebnasab |Bo Xia |Jeffrey S. Stern |Weimin Zhang |Jacqueline I. Kim | +20 more
AbstractIn a previous study, heart xenografts from 10-gene-edited pigs transplanted into two human decedents did not show evidence of acute-onset cellular- or antibody-mediated rejection. Here, to better understand the detailed molecular landscape following xenotransplantation, we carried out bulk and single-cell transcriptomics, lipidomics, proteomics and metabolomics on blood samples obtained from the transplanted decedents every 6 h, as well as histological and transcriptomic tissue profiling.
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May 16, 2024 | 00328-9?rss=yes&sz=64)
cell.com | Raquel Ordoñez |Weimin Zhang |Gwen Ellis |Yinan Zhu |André M. Ribeiro-dos-Santos |Ran Brosh | +5 more
Genomic context critically modulates regulatory function but is difficult to manipulate systematically. The murine insulin-like growth factor 2 (Igf2)/H19 locus is a paradigmatic model of enhancer selectivity, whereby CTCF occupancy at an imprinting control region directs downstream enhancers to activate either H19 or Igf2. We used synthetic regulatory genomics to repeatedly replace the native locus with 157-kb payloads, and we systematically dissected its architecture.
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Apr 16, 2024 | 
epjap.epj.org | Ming Shi |South-Central Minzu |Weimin Zhang |Ling Wang
Eur. Phys. J. Appl. Phys.
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Apr 15, 2024 | 
onlinelibrary.wiley.com | Yusheng Chen |Hanlin L Wang |Hu Chen |Weimin Zhang
Artificial brain is conceived as advanced intelligence technology, capable to emulate in-memory processes occurring in the human brain by integrating synaptic devices. Within this context, improving the functionality of synaptic transistors to increase information processing density in neuromorphic chips is a major challenge in this field.
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Feb 28, 2024 | 
nature.com | Bo Xia |Weimin Zhang |Xinru Zhang |Ran Brosh |Aleksandra Wudzinska |Yu Zhao | +2 more
AbstractThe loss of the tail is among the most notable anatomical changes to have occurred along the evolutionary lineage leading to humans and to the ‘anthropomorphous apes’1,2,3, with a proposed role in contributing to human bipedalism4,5,6. Yet, the genetic mechanism that facilitated tail-loss evolution in hominoids remains unknown. Here we present evidence that an individual insertion of an Alu element in the genome of the hominoid ancestor may have contributed to tail-loss evolution.
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Sep 29, 2023 | 
nature.com | Weimin Zhang
AbstractCholesterol homeostasis has been implicated in the regulation of cellular and body metabolism. Hence, deregulated cholesterol homeostasis leads to the development of many diseases such as cardiovascular diseases, and neurodegenerative diseases, among others. Recent studies have unveiled the connection between abnormal cholesterol metabolism and cancer development. Cholesterol homeostasis at the cellular level dynamically circulates between synthesis, influx, efflux, and esterification.
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Sep 14, 2023 | 
nature.com | Weimin Zhang
AbstractSepsis, a life-threatening condition caused by an inflammatory response to systemic infection, results in a significant social burden and healthcare costs. This study aimed to investigate the relationship between the C-reactive protein (CRP) trajectories of patients with sepsis in the intensive care unit (ICU) and the in-hospital mortality rate.
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Jul 13, 2023 | 
onlinelibrary.wiley.com | Yusheng Chen |Hanlin L Wang |Hu Chen |Weimin Zhang
1 Introduction During the last decade, the controlled incorporation of functional molecules in semiconducting matrices has been demonstrated as a powerful approach to fabricate multifunctional devices. Such a strategy is particularly suitable when employing photochromic molecules for the development of light-responsive and thus optically controllable and programmable electrical devices.
