Brian T. Abe

May 17, 2024 | cell.com | Byzova T.V |Laura Amaya |Brian T. Abe |Jie Liu

Highlights•Extracellular circRNA is internalized by select immune cells in an active process•CircRNA uptake can lead to translation and antigen presentation•CircRNA internalization induces macrophage activation and distinct gene expression•CRISPR screen identifies MSR1 receptor-mediated phagocytosis and macropinocytosisSummaryCircular RNAs (circRNAs) are stable RNAs present in cell-free RNA, which may comprise cellular debris and pathogen genomes.