Byzova T.V

May 17, 2024 | cell.com | Byzova T.V |Laura Amaya |Brian T. Abe |Jie Liu

Highlights•Extracellular circRNA is internalized by select immune cells in an active process•CircRNA uptake can lead to translation and antigen presentation•CircRNA internalization induces macrophage activation and distinct gene expression•CRISPR screen identifies MSR1 receptor-mediated phagocytosis and macropinocytosisSummaryCircular RNAs (circRNAs) are stable RNAs present in cell-free RNA, which may comprise cellular debris and pathogen genomes.

Feb 24, 2024 | cell.com | Byzova T.V |Jose Herrera |José Herrera |Masanobu Komatsu

Highlights•Quiescent endothelial cells guide quiescence of neighboring cells via cell contact•This contact inhibition is mediated by Akt3 and applied by Jagged1•Cell contact provides feedback reinforcement of the barrier in the neighborhood•R-Ras-Akt3-Jagged1-mediated intercellular crosstalk provides angiostasisSummaryCommunication between adjacent endothelial cells is important for the homeostasis of blood vessels.