Brooke Wolford

Seattle

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Articles

A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans - Communications Biology

Apr 8, 2024 | nature.com | Marta R. Moksnes |Brooke Wolford |Laurent Thomas |Humaira Rasheed |Anne Lise Brantsæter |Wei Zhou | +9 more

AbstractTrace elements are important for human health but may exert toxic or adverse effects. Mechanisms of uptake, distribution, metabolism, and excretion are partly under genetic control but have not yet been extensively mapped. Here we report a comprehensive multi-element genome-wide association study of 57 essential and non-essential trace elements.
Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target - Nature Genetics

Oct 16, 2023 | nature.com | Tanmoy Roychowdhury |Derek Klarin |Michael Levin |Joshua M. Spin |Colwyn A. Headley |Noah Tsao | +44 more

AbstractAbdominal aortic aneurysm (AAA) is a common disease with substantial heritability. In this study, we performed a genome-wide association meta-analysis from 14 discovery cohorts and uncovered 141 independent associations, including 97 previously unreported loci. A polygenic risk score derived from meta-analysis explained AAA risk beyond clinical risk factors.

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