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Dec 2, 2024 | 
onlinelibrary.wiley.com | Michael Levin
1 Introduction While the current biomedical/pharmacological paradigm has become increasingly effective at controlling molecular-level events with drugs, true regenerative medicine still eludes us, particularly in the area of anatomical control. We are unable to predict and repair most classes of birth defects or restore damaged or missing organs and appendages. We resort to toxic chemotherapies in the face of cancer [1].
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Nov 30, 2024 | 
nature.com | Joshua Rosenheim |Claire Broderick |Loukas Papargyris |Andrew Kwok |Helen R. Wagstaffe |Emily Conibear | +15 more
AbstractBlood transcriptional biomarkers of acute viral infections typically reflect type 1 interferon (IFN) signalling, but it is not known whether there are biological differences in their regulation that can be leveraged for distinct translational applications. We use high frequency sampling in the SARS-CoV-2 human challenge model to show induction of IFN-stimulated gene (ISG) expression with different temporal and cellular profiles.
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Nov 13, 2024 | 
jamanetwork.com | Joseph Park |Michael Levin |David Zhang |Nosheen Reza
Bidirectional Risk Modulator and Modifier Variant of Dilated and Hypertrophic Cardiomyopathy in BAG3 Key PointsQuestion What is the association of BAG3 genetic variation with penetrance and longitudinal outcomes of dilated cardiomyopathy (DCM)?
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Sep 18, 2024 | 
nature.com | Michael Carter |Heather Jackson |Nedyalko Petrov |Paul Wellman |Jonathan Cohen |Samuel Nichols | +11 more
AbstractSevere febrile illnesses in children encompass life-threatening organ dysfunction caused by diverse pathogens and other severe inflammatory syndromes. A comparative approach to these illnesses may identify shared and distinct features of host immune dysfunction amenable to immunomodulation.
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Mar 27, 2024 | 
nature.com | Michael Levin
AbstractA defining feature of biology is the use of a multiscale architecture, ranging from molecular networks to cells, tissues, organs, whole bodies, and swarms. Crucially however, biology is not only nested structurally, but also functionally: each level is able to solve problems in distinct problem spaces, such as physiological, morphological, and behavioral state space.
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Nov 8, 2023 | 
jamanetwork.com | Michael Levin |Stephen Burgess
Mendelian Randomization and Cardiovascular Disease—Enabling Expert Readership A robust preclinical pipeline of evidence is the ideal prerequisite needed for responsible design and cost-sensitive execution of sometimes multimillion dollar cardiovascular-event–driven randomized clinical trials.
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Nov 8, 2023 | 
jamanetwork.com | Michael Levin |Stephen Burgess
Abstract
Importance
Mendelian randomization (MR) is a statistical approach that has become increasingly popular in the field of cardiovascular disease research. It offers a way to infer potentially causal relationships between risk factors and outcomes using observational data, which is particularly important in cases where randomized clinical trials are not feasible or ethical.
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Oct 16, 2023 | 
nature.com | Tanmoy Roychowdhury |Derek Klarin |Michael Levin |Joshua M. Spin |Colwyn A. Headley |Noah Tsao | +44 more
AbstractAbdominal aortic aneurysm (AAA) is a common disease with substantial heritability. In this study, we performed a genome-wide association meta-analysis from 14 discovery cohorts and uncovered 141 independent associations, including 97 previously unreported loci. A polygenic risk score derived from meta-analysis explained AAA risk beyond clinical risk factors.
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May 19, 2023 | 
pubmed.ncbi.nlm.nih.gov | Michael Levin
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Mar 30, 2023 | 
nature.com | Sarah J Buddle |José Afonso Guerra-Assunção |Moradi Marjaneh |Nathaniel Storey |Luis A. Campos |Luís Campos | +21 more
AbstractSince its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods.
