Bruno Raposo

Jun 9, 2024 | nature.com | Bruno Raposo |Lars Klareskog |William Robinson |Vivianne Malmström

AbstractSince entering the stage 25 years ago as a highly specific serological biomarker for rheumatoid arthritis, anti-citrullinated protein antibodies (ACPAs) have been a topic of extensive research. This hallmark B cell response arises years before disease onset, displays interpatient autoantigen variability, and is associated with poor clinical outcomes.