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3 weeks ago | 02176-3/fulltext&sz=64)
jbc.org | Tiing Jen Loh |Ravi Sharma |Lars Klareskog
IntroductionRheumatoid arthritis (RA) is a T cell-mediated autoimmune disease which affects primarily the joints, and its progression leads to significant morbidity and reduced life expectancy. The disease has a prevalence of 0.5% worldwide and over 500,000 people in Australia (1,2). A hallmark characteristic of RA is the presence of anti-citrullinated protein antibodies (ACPA) in sera, for which >70% of the RA patients being ACPA seropositive in established RA and prior to disease onset (3-9).
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Aug 19, 2024 | 
unt.se | Lars Klareskog
Lokalt Visa alla orter Uppsala Östhammar Tierp Knivsta Heby Älvkarleby Sigtuna Enköping Håbo Nyheter Senaste nytt Blåljus Ekonomi Valresultat Sport Visa all sport Livesport Senaste nytt Sirius Fotboll Uppsala Fotboll Gusk Dalkurd Almtuna IS Sirius Bandy Storvreta IBK Sirius IBK Hagunda Uppsala Basket SSL Resultat Familj Familjenyheter Se dödsannonser (Till minne) Se familjeannonser Se köp och sälj Skicka in minnesord Skicka in familjeannonser Skicka in Dagens ros Åsikter Alla åsikter Ledare...
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Jun 9, 2024 | 
nature.com | Bruno Raposo |Lars Klareskog |William Robinson |Vivianne Malmström
AbstractSince entering the stage 25 years ago as a highly specific serological biomarker for rheumatoid arthritis, anti-citrullinated protein antibodies (ACPAs) have been a topic of extensive research. This hallmark B cell response arises years before disease onset, displays interpatient autoantigen variability, and is associated with poor clinical outcomes.
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May 23, 2024 | 
acrjournals.onlinelibrary.wiley.com | Anton Öberg Sysojev |Lars Alfredsson |Lars Klareskog |Gilad Silberberg
INTRODUCTION Patients with rheumatoid arthritis (RA) are at increased risk of various comorbid conditions.1-3 Of these, cardiovascular disease (CVD) is among the most prevalent, with studies suggesting a 50% increased risk of CVD incidence among patients with RA compared to the general population.4, 5 Although CVD risk factors are more prevalent among patients with RA than the general population, such factors do not alone explain the entirety of the excess risk,6, 7 leading researchers to...
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Feb 15, 2024 | 
ard.bmj.com | Eleftheria Pertsinidou |Saedis Saevarsdottir |Vivek Anand Manivel |Lars Klareskog
In early rheumatoid arthritis, anticitrullinated peptide antibodies associate with low number of affected joints and rheumatoid factor associates with systemic inflammation Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
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Nov 27, 2023 | 
ard.bmj.com | Eleftheria Pertsinidou |Saedis Saevarsdottir |Vivek Anand Manivel |Lars Klareskog
DiscussionIn our study, presence of ACPA associated with lower number of swollen and tender joints in the RF-negative group, whereas presence of IgM RF associated with increased inflammatory markers, especially ESR, dependent on the co-occurrence of ACPA. In other words, in early RA, RF and ACPA associate with different individual DAS28 components and in opposite directions.
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Sep 22, 2023 | 
acrjournals.onlinelibrary.wiley.com | Lars Alfredsson |Lars Klareskog |Solna Sweden
To the Editor: We are grateful for the constructive engagement with our article from Xie et al,1 Lin et al,2 and Wang et al3 and have the following comments to their questions and concerns. Xie et al raise concerns regarding the potential influence of drug use on our study results.1 We examined this aspect by adjusting for treatment categorized into groups of specific disease-modifying antirheumatic drugs, which yielded results similar to our dichotomous categorization.
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Sep 7, 2023 | 
nature.com | Niclas Eriksson |Erin Macdonald-Dunlop |Stefan Enroth |Domenico Cozzetto |Lasse Folkersen |Christian Herder | +16 more
Correction to: Nature Immunology https://doi.org/10.1038/s41590-023-01588-w, published online 10 August 2023. In the version of the article originally published, the middle panel in Fig. 3b was mistakenly a duplicate of the upper panel. The figure has now been corrected in the HTML and PDF versions of the article.
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Aug 10, 2023 | 
nature.com | Niclas Eriksson |Erin Macdonald-Dunlop |Stefan Enroth |Domenico Cozzetto |Lasse Folkersen |Christian Herder | +16 more
AbstractCirculating proteins have important functions in inflammation and a broad range of diseases. To identify genetic influences on inflammation-related proteins, we conducted a genome-wide protein quantitative trait locus (pQTL) study of 91 plasma proteins measured using the Olink Target platform in 14,824 participants. We identified 180 pQTLs (59 cis, 121 trans).
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Jul 3, 2023 | 
nature.com | Asmundur Oddsson |Patrick Sulem |Gardar Sveinbjornsson |Gudny A. Arnadottir |Valgerdur Steinthorsdottir |Gísli H. Halldórsson | +41 more
Author notesThese authors contributed equally: Asmundur Oddsson, Patrick Sulem. These authors jointly supervised this work: Kari Stefansson, Daniel F. Gudbjartsson. Authors and AffiliationsdeCODE genetics/Amgen, Inc., Reykjavik, IcelandAsmundur Oddsson, Patrick Sulem, Gardar Sveinbjornsson, Gudny A. Arnadottir, Valgerdur Steinthorsdottir, Gisli H. Halldorsson, Bjarni A. Atlason, Gudjon R. Oskarsson, Hannes Helgason, Hildigunnur Katrinardottir, Run Fridriksdottir, Brynjar O.
