Bryan T. Grenfell

Apr 24, 2024 | biorxiv.org | Sarah Cobey |JESSICA METCALF |Jonathan Levine |Bryan T. Grenfell

AbstractA key aim in the dynamics and control of infectious diseases is predicting competitive outcomes of pathogen interactions. Observed pathogen community structure indicates both considerable coexistence of related variants and spectacular instances of replacement, notably in seasonal influenza and SARS-CoV-2. However, an overall comparative quantitative framework for invasion and coexistence remains elusive.

Dec 10, 2023 | onlinelibrary.wiley.com | Cécile Viboud |Bryan T. Grenfell |Alexandra B Hogan |Samantha J. Bents

1 INTRODUCTION Respiratory syncytial virus (RSV) is the most common cause of lower respiratory infections and is responsible for an estimated 5% of under-five mortality globally.1 The majority of RSV disease burden is concentrated in low-resource settings, with 97% of all RSV-related deaths occurring in low- and middle-income countries (LMICs).2 Almost all children are infected by the age of 2 years, but severe infections occur primarily in infants under 6 months of age.3-5 Given the short...