Byeong Seob Oh

Oct 28, 2024 | microbiologyresearch.org | Ji-Young Lee |Ji-young Lee |Eun Seon Chung |Yuxin Peng |Byeong Seob Oh

Purpose. It is known that the arnB (or pmrH) gene encoding uridine 5′-(beta-1-threo-pentapyranosyl-4-ulose diphosphate) aminotransferase plays a critical role in colistin resistance in Pseudomonas aeruginosa through the addition of 4-amino-4-deoxy-l-arabinose (l-Ara4N) to lipid A. In this study we attempted to obtain a colistin-resistant mutant from an arnB-deleted mutant through exposure to colistin. Methodology.