Byrne A.B

Dec 11, 2023 | cell.com | Byrne A.B |Douglas Fowler |Heidi Rehm

SummaryIn 2020, the National Human Genome Research Institute (NHGRI) made ten “bold predictions,” including that “the clinical relevance of all encountered genomic variants will be readily predictable, rendering the diagnostic designation ‘variant of uncertain significance (VUS)’ obsolete.” We discuss the prospects for this prediction, arguing that many, if not most, VUS in coding regions will be resolved by 2030.

Sep 27, 2023 | cell.com | Alexandra Byrne |Byrne A.B |Casey Baker |Matthew A Gomes

Highlights•The HSN neuron elicits acute egg laying and speeding, as well as long-term slowing•HSN controls egg laying and speeding using distinct transmitters and compartments•HSN promotes long-term slowing through serotonin release•HSN serotonin is taken up and re-released by NSM neurons, which drive slowingSummaryAnimals generate a wide range of highly coordinated motor outputs, which allows them to execute purposeful behaviors.

Sep 22, 2023 | jbc.org | Byrne A.B |Molecular Biotechnology |Paul Thompson

ABSTRACTAxonal degeneration is a hallmark feature of neurodegenerative diseases. Activation of the NAD(P)ase SARM1 is critical for this process. In resting neurons, SARM1 activity is inhibited, but upon damage, SARM1 is activated and catalyzes one of three NAD(P)+ dependent reactions: 1) NAD(P)+ hydrolysis to form ADP-ribose (ADPR[P]) and nicotinamide; 2) the formation of cyclic-ADPR (cADPR[P]); or 3) a base exchange reaction with nicotinic acid (NA) and NADP+ to form NAADP.