Molecular Biotechnology

Oct 3, 2024 | cell.com | Molecular Biotechnology |Dibyendu Kumar Das

KeywordsSARS-CoV-2coronavirusviral entrymembrane fusionsingle molecule imagingconformational dynamicssmFRETGet full text accessLog in, subscribe or purchase for full access. References1. Harrison, S.C.Viral membrane fusionVirology. 2015; 479–480:498-5072. Kielian, M. Mechanisms of virus membrane fusion proteinsAnnu. Rev. Virol. 2014; 1:171-1893. Meng, B. ∙ Abdullahi, A. ∙ Ferreira, I.A.T.M. ... Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicityNature. 2022; 603:706-7144.

Sep 22, 2023 | jbc.org | Byrne A.B |Molecular Biotechnology |Paul Thompson

ABSTRACTAxonal degeneration is a hallmark feature of neurodegenerative diseases. Activation of the NAD(P)ase SARM1 is critical for this process. In resting neurons, SARM1 activity is inhibited, but upon damage, SARM1 is activated and catalyzes one of three NAD(P)+ dependent reactions: 1) NAD(P)+ hydrolysis to form ADP-ribose (ADPR[P]) and nicotinamide; 2) the formation of cyclic-ADPR (cADPR[P]); or 3) a base exchange reaction with nicotinic acid (NA) and NADP+ to form NAADP.

May 4, 2023 | academic.oup.com | Molecular Biotechnology |Bioinformatics Group |van Wezel |Eric J N

Microorganisms produce small bioactive compounds as part of their secondary or specialised metabolism. Often, such metabolites have antimicrobial, anticancer, antifungal, antiviral or other bio-activities and thus play an important role for applications in medicine and agriculture. In the past decade, genome mining has become a widely-used method to explore, access, and analyse the available biodiversity of these compounds.

Feb 6, 2023 | frontiersin.org | Molecular Biotechnology

Anthony Imbalzano1* and Tapan Sharma1 1BIochemistry and Molecular Biotechnology, University of Massachusetts Medical School, United States The final, formatted version of the article will be published soon.