Molecular Biotechnology

Oct 3, 2024 | cell.com | Molecular Biotechnology |Dibyendu Kumar Das

KeywordsSARS-CoV-2coronavirusviral entrymembrane fusionsingle molecule imagingconformational dynamicssmFRETGet full text accessLog in, subscribe or purchase for full access. References1. Harrison, S.C.Viral membrane fusionVirology. 2015; 479–480:498-5072. Kielian, M. Mechanisms of virus membrane fusion proteinsAnnu. Rev. Virol. 2014; 1:171-1893. Meng, B. ∙ Abdullahi, A. ∙ Ferreira, I.A.T.M. ... Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicityNature. 2022; 603:706-7144.

Sep 22, 2023 | jbc.org | Byrne A.B |Molecular Biotechnology |Paul Thompson

ABSTRACTAxonal degeneration is a hallmark feature of neurodegenerative diseases. Activation of the NAD(P)ase SARM1 is critical for this process. In resting neurons, SARM1 activity is inhibited, but upon damage, SARM1 is activated and catalyzes one of three NAD(P)+ dependent reactions: 1) NAD(P)+ hydrolysis to form ADP-ribose (ADPR[P]) and nicotinamide; 2) the formation of cyclic-ADPR (cADPR[P]); or 3) a base exchange reaction with nicotinic acid (NA) and NADP+ to form NAADP.