Byrne E.F.X

Apr 17, 2024 | cell.com | Byrne E.F.X |T. Bertie Ansell |Megan Healy

Highlights•MBOAT subfamilies differentially distort the surrounding bilayer•Conserved residue pairs on re-entrant loop-2 stabilize the MBOAT fold•A conserved hydrogen bond interconnects the DGAT1 dimer•Solvent gating and hydration properties differ across the familySummaryMembrane-bound O-acyltransferases (MBOATs) are membrane-embedded enzymes that catalyze acyl chain transfer to a diverse group of substrates, including lipids, small molecules, and proteins.