T. Bertie Ansell

Oct 10, 2024 | pubs.acs.org | Davis Perez |Dara P. Dowlatshahi |Christopher A. Azaldegui |T. Bertie Ansell

Journal of the American Chemical SocietyCite this: J. Am. Chem. Soc. 2024, XXXX, XXXClick to copy citationCitation copied!. This publication is licensed under CC-BY-NC-ND 4.0 . You are free to share (copy and redistribute) this article in any medium or format within the parameters below:Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Non-Commercial (NC): Only non-commercial uses of the work are permitted.

Oct 10, 2024 | dx.doi.org | Davis Perez |Dara P. Dowlatshahi |Christopher A. Azaldegui |T. Bertie Ansell

Journal of the American Chemical SocietyCite this: J. Am. Chem. Soc. 2024, XXXX, XXXClick to copy citationCitation copied!. This publication is licensed under CC-BY-NC-ND 4.0 . You are free to share (copy and redistribute) this article in any medium or format within the parameters below:Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Non-Commercial (NC): Only non-commercial uses of the work are permitted.

Apr 17, 2024 | cell.com | Byrne E.F.X |T. Bertie Ansell |Megan Healy

Highlights•MBOAT subfamilies differentially distort the surrounding bilayer•Conserved residue pairs on re-entrant loop-2 stabilize the MBOAT fold•A conserved hydrogen bond interconnects the DGAT1 dimer•Solvent gating and hydration properties differ across the familySummaryMembrane-bound O-acyltransferases (MBOATs) are membrane-embedded enzymes that catalyze acyl chain transfer to a diverse group of substrates, including lipids, small molecules, and proteins.

Dec 18, 2023 | biorxiv.org | T. Bertie Ansell |Megan Healy |Claire Coupland |Mark Sansom

AbstractMembrane Bound O-acyltransferases (MBOATs) are membrane embedded enzymes which catalyse acyl chain transfer to a diverse group of substrates including lipids, small-molecules and proteins. Recent MBOAT structures reveal a conserved structural core, despite wide-ranging functional specificity across both prokaryotes and eukaryotes.

Aug 23, 2023 | science.org | Sarah Hoy |Josh Peters |Runzi Sun |T. Bertie Ansell

File failed to load: https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/extensions/MathMenu.js Research ArticleBIOPHYSICS INTRODUCTIONDiscerning the direction, energetics, and stoichiometries of substrate transport by membrane proteins is essential for a holistic understanding of their molecular functions.