Byrne M.D

Oct 30, 2023 | jbc.org | Byrne M.D |Matthew R. Pratt |David J. Vocadlo |Simon FRASER

AbstractO-GlcNAc is a common modification found on nuclear and cytoplasmic proteins. Determining the catalytic mechanism of the enzyme O-GlcNAcase (OGA), which removes O-GlcNAc from proteins, enabled the creation of potent and selective inhibitors of this regulatory enzyme. Such inhibitors have served as important tools in helping to uncover the cellular and organismal physiological roles of this modification.