Byrnes K.R

Aug 17, 2024 | cell.com | Byrnes K.R |Byrska-Bishop M |Neurological Institute-Hospital |Platon Megagiannis

Highlights•Astrocytic CHD8 in the adult brain regulates injury-induced reactive gliosis•Astrocytic CHD8 in the adult brain controls LPS-induced neuroinflammation•Astrocytic CHD8 regulates chromatin accessibility and transcription during neuroinflammation•AAV- and CRISPR-mediated direct Chd8 editing in astrocytes in vivo attenuates reactive gliosisSummaryReactive changes of glial cells during neuroinflammation impact brain disorders and disease progression.