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Aug 17, 2024 | 00987-2&sz=64)
cell.com | Byrnes K.R |Byrska-Bishop M |Neurological Institute-Hospital |Platon Megagiannis
Highlights•Astrocytic CHD8 in the adult brain regulates injury-induced reactive gliosis•Astrocytic CHD8 in the adult brain controls LPS-induced neuroinflammation•Astrocytic CHD8 regulates chromatin accessibility and transcription during neuroinflammation•AAV- and CRISPR-mediated direct Chd8 editing in astrocytes in vivo attenuates reactive gliosisSummaryReactive changes of glial cells during neuroinflammation impact brain disorders and disease progression.
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Jul 10, 2024 | 00213-1&sz=64)
cell.com | Byrska-Bishop M |Elizabeth Plender |Timofey Prodanov |Heinrich Heine
SummaryThe secreted mucins MUC5AC and MUC5B are large glycoproteins that play critical defensive roles in pathogen entrapment and mucociliary clearance. Their respective genes contain polymorphic and degenerate protein-coding variable number tandem repeats (VNTRs) that make the loci difficult to investigate with short reads. We characterize the structural diversity of MUC5AC and MUC5B by long-read sequencing and assembly of 206 human and 20 nonhuman primate (NHP) haplotypes.
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Jun 14, 2024 | 00328-9?rss=yes&sz=64)
cell.com | Byrska-Bishop M |Karl Kumbier |Julia R. Lazzari-Dean
Highlights•Molecular ALS phenotype scores (MAPs) discriminate FUS fALS from healthy fibroblasts•Imaging and transcriptomics MAPs show strong concordance•Imaging MAPs quantify shifts of FUS ALS phenotype toward health upon FUS ASO treatmentSummaryAmyotrophic lateral sclerosis (ALS) is a rapidly progressing, highly heterogeneous neurodegenerative disease, underscoring the importance of obtaining information to personalize clinical decisions quickly after diagnosis.
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Jun 4, 2024 | 00177-0&sz=64)
cell.com | Byrska-Bishop M |Changbo Yang |Yujie Liu |Chongwen Lv
SummaryNumerous variants, including both single-nucleotide variants (SNVs) in DNA and A>G RNA edits in mRNA as essential drivers of cellular proliferation and tumorigenesis, are commonly associated with cancer progression and growth. Thus, mining and summarizing single-cell variants will provide a refined and higher-resolution view of cancer and further contribute to precision medicine.
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Apr 5, 2024 | 00252-6&sz=64)
cell.com | Byrska-Bishop M |Ya Cui |Wenbin Ye |Jingyi Li
Highlights • A biobank-scale reference of 0.86 million TRs derived from 338,963 humans • A TR reference map for diverse ancestries, including 39.5% non-European samples • Critical insights into the prevalence of ancestry-specific TR disorders • An invaluable resource for interpreting TR expansions in diseases Summary The Genome Aggregation Database (gnomAD), widely recognized as the gold-standard reference map of human genetic variation, has largely overlooked tandem repeat (TR) expansions,...
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Feb 27, 2024 | 00034-x&sz=64)
cell.com | Byrska-Bishop M |Rui Martiniano |Liverpool John Moores |Marc Haber
Highlights • Successful sequencing of four ancient genomes from Tylos-period Bahrain • Genetic composition formed of ancient Anatolia, Levant, and Caucasus/Iran ancestries • Genetic affinities to present-day inhabitants of Iraq and the Levant • Evidence of malaria adaptation at the onset of agriculture in Eastern Arabia Summary The harsh climate of Arabia has posed challenges in generating ancient DNA from the region, hindering the direct examination of ancient genomes for understanding the...
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Nov 22, 2023 | 01513-0&sz=64)
cell.com | Byrnes J.K |Byrska-Bishop M |Francesco Ravasini |Francesco Montinaro
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Nov 22, 2023 | 02517-6/abstract&sz=64)
jbc.org | Byrska-Bishop M |Felix Paul Lohmann |James J. Bieker
AbstractEKLF/KLF1 is an essential transcription factor that plays a global role in erythroid transcriptional activation. Regulation of KLF1 is of interest, as it displays a highly restricted expression pattern, limited to erythroid cells and its progenitors. Here we use biochemical affinity purification to identify the DDX5/p68 protein as an activator of KLF1 by virtue of its interaction with the erythroid-specific DNAse hypersensitive site upstream enhancer element (EHS1).
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Nov 6, 2023 | 
futuremedicine.com | Byrska-Bishop M |Evani US |Ross P Booyse |David Twesigomwe
FiguresReferencesRelatedDetails Supplemental MaterialsMetricsHistoryReceived 24 August 2023 Accepted 12 October 2023 Published online 6 November 2023 Information© 2023 Future Medicine LtdSupplementary dataTo view the supplementary data that accompany this paper please visit the journal website at: www.futuremedicine.com/doi/suppl/10.2217/pgs-2023-0166Author contributionsRP Booyse, D Twesigomwe and S Hazelhurst designed the study.
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Sep 27, 2023 | 
futuremedicine.com | Byrne AJ |Byrska-Bishop M |Smarr CB |Hsu C-L
Department of Endocrinology, the Second Hospital of Jilin University, Changchun, 130000, China Department of Thyroid Surgery, the Second Hospital of Jilin University, Changchun, 130000, China Department of Endocrinology, the Second Hospital of Jilin University, Changchun, 130000, China Department of Thyroid Surgery, the Second Hospital of Jilin University, Changchun, 130000, China Nanotechnology has significant potential for cancer management at all stages, including prevention, diagnosis and...
