Byron Caughey

Apr 16, 2024 | nature.com | Robert Horne |Ewa Andrzejewska |Pietro Sormanni |Byron Caughey

AbstractMachine learning methods hold the promise to reduce the costs and the failure rates of conventional drug discovery pipelines. This issue is especially pressing for neurodegenerative diseases, where the development of disease-modifying drugs has been particularly challenging. To address this problem, we describe here a machine learning approach to identify small molecule inhibitors of α-synuclein aggregation, a process implicated in Parkinson’s disease and other synucleinopathies.

Jun 21, 2023 | biorxiv.org | Byron Caughey |Robert Horne |Ewa Andrzejewska |Parvez Alam

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