Robert Horne

2 months ago | nature.com | Robert Horne |Sarah Sandler |Michele Vendruscolo

AbstractPowerful single-molecule approaches have been developed for the accurate measurement of protein oligomers, but they are often low throughput and limited to the measurement of specific systems. To overcome this problem, nanopore-based detection holds the promise of providing the high throughput, broad applicability, and accuracy necessary to characterize protein oligomers in a variety of contexts.

Nov 19, 2024 | paysonroundup.com | Robert Horne

Thank you supervisorsThe Gila County Board of Supervisors took the time and effort to respond positively to my request for $1,000 for our clothing nonprofit, Kaitie’s Closet. In fact, they amended the request and provided us with a check for $3,000. Given that we have spent more than $5,000 on new shoes alone in the calendar year, their caring attitude for struggling children gladdened my heart while humbling me at the same time.

Nov 1, 2024 | paysonroundup.com | Robert Horne

The result is stagnationI was depressed by the not unexpected news reported in the Roundup that Payson could not find buyers for the proposed $70 million dollar bond issue. The culprits in this losing situation are those locals with limited vision among us who cannot bring themselves to embrace the future. Those of us who look forward to building a vibrant, competitive city have been defeated, once again, by folks who wish to cling to the past.

Sep 3, 2024 | paysonroundup.com | Robert Horne

We need to walk to walkOn Nov. 7, many of us shall have the opportunity to assist the children attending PUSD in a meaningful way. Approving the 10% maintenance and operation budget override will ensure the continued funding of programs already in existence, which are critical to the educational success of our public schools.

Apr 16, 2024 | nature.com | Robert Horne |Ewa Andrzejewska |Pietro Sormanni |Byron Caughey

AbstractMachine learning methods hold the promise to reduce the costs and the failure rates of conventional drug discovery pipelines. This issue is especially pressing for neurodegenerative diseases, where the development of disease-modifying drugs has been particularly challenging. To address this problem, we describe here a machine learning approach to identify small molecule inhibitors of α-synuclein aggregation, a process implicated in Parkinson’s disease and other synucleinopathies.