Byrum S.D

Jan 11, 2024 | cell.com | Byrum S.D

Highlights•2-thio-dTTP facilitates the generation of mutation signatures at 6mA-modified sites•DR-6mA-seq enables base-resolution quantitative 6mA profiling in mammalian genome•6mA is upregulated in the glioblastoma model cell line and co-localizes with H3K27me3SummaryAlthough DNA N6-methyl-deoxyadenosine (6mA) is abundant in bacteria and protists, its presence and function in mammalian genomes have been less clear.

Nov 14, 2023 | cell.com | Byrum S.D |Byrne C.J |Sun Yat-sen

Highlights•The tumor suppressor p53 transcriptionally induces CMBL expression•CMBL promotes TRIM25-induced ubiquitination and degradation of PFKP•CMBL inhibits glycolysis and the growth of CRC cells•p53-inducing agents and 2-DG coordinately suppress CMBL-deficient CRCSummaryAerobic glycolysis is critical for cancer progression and can be exploited in cancer therapy.