C. Mark Smales

Dec 6, 2023 | nature.com | Juan Carlos Yam-Puc |Emily Horner |Alexander J. Mentzer |Kathryn S. Lilley |C. Mark Smales |Susanna J. Dunachie

AbstractIn vitro-transcribed (IVT) mRNAs are modalities that can combat human disease, exemplified by their use as vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). IVT mRNAs are transfected into target cells, where they are translated into recombinant protein, and the biological activity or immunogenicity of the encoded protein exerts an intended therapeutic effect1,2.