Susanna J. Dunachie

Apr 15, 2024 | nature.com | Chang Liu |Aiste Dijokaite-Guraliuc |Daming Zhou |Alexander J. Mentzer |Thomas Ritter |Nigel Temperton | +8 more

AbstractThe rapid evolution of SARS-CoV-2 is driven in part by a need to evade the antibody response in the face of high levels of immunity. Here, we isolate spike (S) binding monoclonal antibodies (mAbs) from vaccinees who suffered vaccine break-through infections with Omicron sub lineages BA.4 or BA.5. Twenty eight potent antibodies are isolated and characterised functionally, and in some cases structurally.

Mar 27, 2024 | nature.com | Daming Zhou |Aiste Dijokaite-Guraliuc |Alexander J. Mentzer |Nigel Temperton |Paul Klenerman |Susanna J. Dunachie | +3 more

AbstractUnder pressure from neutralising antibodies induced by vaccination or infection the SARS-CoV-2 spike gene has become a hotspot for evolutionary change, leading to the failure of all mAbs developed for clinical use. Most potent antibodies bind to the receptor binding domain which has become heavily mutated.

Dec 6, 2023 | nature.com | Juan Carlos Yam-Puc |Emily Horner |Alexander J. Mentzer |Kathryn S. Lilley |C. Mark Smales |Susanna J. Dunachie

AbstractIn vitro-transcribed (IVT) mRNAs are modalities that can combat human disease, exemplified by their use as vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). IVT mRNAs are transfected into target cells, where they are translated into recombinant protein, and the biological activity or immunogenicity of the encoded protein exerts an intended therapeutic effect1,2.

Apr 24, 2023 | nature.com | Yavuz F. Yazicioglu |Ciaran Sandhu |Barbara Kronsteiner |Moustafa Attar |Susanna J. Dunachie |Michael L. Dustin

AbstractGerminal center (GC) B cells undergo proliferation at very high rates in a hypoxic microenvironment but the cellular processes driving this are incompletely understood. Here we show that the mitochondria of GC B cells are highly dynamic, with significantly upregulated transcription and translation rates associated with the activity of transcription factor A, mitochondrial (TFAM).