Caleb C. Reagor

Oct 18, 2024 | biorxiv.org | Caleb C. Reagor |A. J. Hudspeth

AbstractLike the sensory organs of the human inner ear, the lateral-line neuromasts (NMs) of fish such as the zebrafish (Danio rerio) contain mechanosensory hair cells (HCs) that are surrounded by progenitors called supporting cells. Damaged NMs can quickly regenerate new HCs by expressing in the progenitors HC-specific genes such as atoh1a, the master regulator of HC fate.

May 1, 2024 | nature.com | Lijuan Hu |Marijn Schipper |Caleb C. Reagor |Xiaofei Li |Xiaoling He |Roger Barker | +2 more

AbstractThe human brain develops through a tightly organized cascade of patterning events, induced by transcription factor expression and changes in chromatin accessibility. Although gene expression across the developing brain has been described at single-cell resolution1, similar atlases of chromatin accessibility have been primarily focused on the forebrain2,3,4.