Roger Barker

1 month ago | nature.com | Roger Barker |Stephen B. Dunnett |Naomi Hannaway |Xiaoling He |Sam Hewitt |Philipp Mahlknecht | +4 more

AbstractTransplantation of human fetal ventral mesencephalic tissue in individuals with Parkinson’s disease has yielded clinical benefits but also side effects, such as graft-induced dyskinesias. The open-label TransEuro trial (NCT01898390) was designed to determine whether this approach could be further developed into a clinically useful treatment.

Nov 20, 2024 | nature.com | J. Patrick Pett |Kenny Roberts |Raphael Blain |Krzysztof Polanski |Peng He |Chuan Xu | +18 more

AbstractHuman embryonic bone and joint formation is determined by coordinated differentiation of progenitors in the nascent skeleton. The cell states, epigenetic processes and key regulatory factors that underlie lineage commitment of these cells remain elusive.

Nov 20, 2024 | nature.com | Nadav Yayon |Lena Boehme |Brianna T. Wachter |Oren Amsalem |Alexander Predeus |Catherine Tudor | +13 more

AbstractT cells develop from circulating precursor cells, which enter the thymus and migrate through specialized subcompartments that support their maturation and selection1. In humans, this process starts in early fetal development and is highly active until thymic involution in adolescence.

May 1, 2024 | nature.com | Lijuan Hu |Marijn Schipper |Caleb C. Reagor |Xiaofei Li |Xiaoling He |Roger Barker | +2 more

AbstractThe human brain develops through a tightly organized cascade of patterning events, induced by transcription factor expression and changes in chromatin accessibility. Although gene expression across the developing brain has been described at single-cell resolution1, similar atlases of chromatin accessibility have been primarily focused on the forebrain2,3,4.

Jun 8, 2023 | nature.com | Franziska Knolle |Roger Barker |Jimmy Lee |Siwei Liu |Graham K Murray |Juan Zhou

AbstractPsychotic symptoms occur in a majority of schizophrenia patients and in ~50% of all Parkinson’s disease (PD) patients. Altered grey matter (GM) structure within several brain areas and networks may contribute to their pathogenesis. Little is known, however, about transdiagnostic similarities when psychotic symptoms occur in different disorders, such as in schizophrenia and PD.