Carla Borrás

United States

Digital Video Director at PBS Frontline

Senior Producer of special projects & innovation @frontlinepbs, documentary dork, coffee addict, sassy Latina. Views my own.

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Restoring Cholesterol Efflux in Vascular Smooth Muscle Cells Transitioning into Foam Cells Through Liver X Receptor Activation

Jan 28, 2025 | biorxiv.org | Carla Borrás |Noemi Rotllan |Raquel Griñán |David Santos

AbstractObjective: Macrophage foam cells derived from vascular smooth muscle cells (VSMCs) account for 30-70% of foam cells in atherosclerotic lesions. Liver X receptor (LXR) agonists promote high-density lipoprotein (HDL)-mediated cholesterol efflux from macrophages. This study aimed to investigate the effects of LXR activation on the reverse cholesterol transport (RCT) rate from VSMCs to feces in vivo.

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