Raquel Griñán

Jan 28, 2025 | biorxiv.org | Carla Borrás |Noemi Rotllan |Raquel Griñán |David Santos

AbstractObjective: Macrophage foam cells derived from vascular smooth muscle cells (VSMCs) account for 30-70% of foam cells in atherosclerotic lesions. Liver X receptor (LXR) agonists promote high-density lipoprotein (HDL)-mediated cholesterol efflux from macrophages. This study aimed to investigate the effects of LXR activation on the reverse cholesterol transport (RCT) rate from VSMCs to feces in vivo.