Carlos Costas-Insua

Aug 24, 2024 | biorxiv.org | Hao-Chih Hung |Carlos Costas-Insua |Sarah Holbrook |Jennifer Stauffer

AbstractThe surveillance of translation is critical for the fitness of organisms from bacteria to humans. Ribosome-associated Quality Control (RQC) is a surveillance mechanism that promotes the elimination of truncated polypeptides, byproducts of ribosome stalling during translation. In canonical mammalian RQC, NEMF binds to the large ribosomal subunit and recruits the E3 ubiquitin ligase Listerin, which marks the nascent-chains for proteasomal degradation.