Carlos H M

May 23, 2024 | academic.oup.com | Molecular Biosciences |Clinical Informatics |Carlos H M

Protein–protein interactions (PPIs) are fundamental to many cellular processes, making them important targets for therapeutic intervention and critical focus in the study of various diseases. PPI sites contain critical areas known as hotspots, which are crucial for the strength and specificity of the interactions (1,2). The stability of these PPIs is vital for cellular equilibrium and the regulation of complex biological activities (3,4).