Carlos Reding

Jan 26, 2024 | biorxiv.org | Jordan E. Sealey |Winnie Lee |Carlos Reding |Punyawee Dulayangkul

AbstractNitrofurantoin resistance in Escherichia coli is primarily caused by mutations damaging two enzymes, NfsA and NfsB. Studies based on small isolate collections with defined nitrofurantoin MICs have found significant random genetic drift in nfsA and nfsB making it extremely difficult to predict nitrofurantoin resistance from whole genome sequence (WGS) where both genes are not obviously disrupted by nonsense or frameshift mutations or insertional inactivation.

Nov 20, 2023 | biorxiv.org | Carlos Reding

AbstractThe link between fitness and reproduction rate is a central tenet in evolutionary biology: Mutants reproducing faster than the dominant wild-type are favoured by selection, but otherwise the mutation is lost. This link is given by Fisher's theorem, under the assumption that fitness can only change through mutations that boost or hinder growth rate, whence the use of logarithms on growth data by experimentalists.