Punyawee Dulayangkul

Jan 26, 2024 | biorxiv.org | Jordan E. Sealey |Winnie Lee |Carlos Reding |Punyawee Dulayangkul

AbstractNitrofurantoin resistance in Escherichia coli is primarily caused by mutations damaging two enzymes, NfsA and NfsB. Studies based on small isolate collections with defined nitrofurantoin MICs have found significant random genetic drift in nfsA and nfsB making it extremely difficult to predict nitrofurantoin resistance from whole genome sequence (WGS) where both genes are not obviously disrupted by nonsense or frameshift mutations or insertional inactivation.