Carolina M. Polonio

3 weeks ago | jci.org | Carolina M. Polonio |Francisco J. Quintana |Jessica Wei |Pierre-Paul Axisa

AbstractB cell depletion is a highly effective therapy in multiple sclerosis (MS), reducing inflammation and restoring immune balance. In this issue of the JCI, Wei et al. used single-cell RNA-Seq and flow cytometry, identifying the comprehensive effects of B cell depletion on the immune response, including an increase in antiinflammatory cerebrospinal fluid macrophages and elevated TNF-α expression by peripheral CD16+ monocytes.